Acrylatesc1030 alkyl acrylate crosspolymer carbopol etd 2020 polymer is an easytodisperse, white powder, crosslinked polyacrylic acid copolymer polymerized in a toxicologicallypreferred cosolvent system specifically designed for thickening surfactant systems. Rheological evaluation of siliconcarbopol hydrophilic gel systems. Jun 27, 20 some of the foregoing polymers are designated under inci nomenclature as acrylatesc1030 alkyl acrylate crosspolymer and are commercially available under the trade names carbopol 42 and 82, carbopol ultrez 20 and 21, carbopol etd 2020, and pemulen tr1 and tr2 from lubrizol advanced materials, inc. Previous works have already demonstrated the possibility of formulating carbopol systems. Carbopol polymers also offer formulation flexibility because they can be used with a variety of pharmaceutical active ingredients for oral, topical, or mucosal delivery. Cream shower bath cold processable formulation on personal.
Nonneutralized samples have a ph ranging between 2. Carbopol 71g nf is the only granular carbomer available for direct compression formulations, providing increased versatility in the manufacture of oral solid dose products. A practical determination of these hsp values would provide higher certainty. The present investigation was aimed at exploitation of the mucoadhesive potential of carbopol 934p polymer in developing microbeads of glipizide glp for its effectivity in controlling blood sugar in diabetic patients. Ir spectrum of carbopol 934p is characterized by principal absorption peaks at 3089. Carbopol etd 2020 polymer is an easytodisperse, white powder. Hence, carbopol etd 2020 was selected for the formulation of mbg. Alkaliswellable emulsion thickener imparting a longer flow to control penetration. Carbopol etd 2020 is specially designed for thickening surfactant systems.
Ir spectrum of chlorhexidine hcl is characterized by principal absorption peaks at 2542, 2956. Nextgeneration carbopol polymer proves highly efficient. Facial cleansing gel formulation on personal care magazine. Carbopol polymer provides highly efficient thickening and excellent clarity, suspending power and emulsion stability. Safety data sheet components cas numberproportion hazard codes cyclohexane 110827 0. This work would be able to provide an important information in the study of rheological attribution of carbopol in application of pharmaceutics and cosmetics. This list of compatible products is generated out of estimated hsp values.
Carbopol etd 2020, crosslinked polyacrylic acid copolymer. Various polymers such as guar gum, hpmck100 m, peg 6000 and carbopol 934 p were employed as polymers. We used three sorts of carbopol with different crosslinking degrees as matrix generating polymers. Endeavours have been made to ensure that the information given is reliable, but notwithstanding this, and except for those obligations and liabilities that cannot be excluded by operation of law, neither surfachem group ltd nor any of its subsidiary or associated companies assume any obligation or liability arising from the information given, the recommendations made or the use of their. Identification of the material and supplier product name.
It is a white powder, crosslinked copolymer of polyacrylic acid that is polymerized in a toxicologicallypreferred cosolvent system. Features and benefits of carbopol ultrez 20 polymer rapid wetting the unique structure of carbopol ultrez 20 polymer allows for rapid wetting and improved swelling time without the need for agitation. Polymers and compositions lubrizol advanced materials, inc. Usually carbopol is neutralized in order to activate maximum viscosity efficiency, yield stress and elasticity. Study of the mucoadhesive potential of carbopol polymer in. Because carbopol 980 is so highly hygroscopic, it absorbs moisture and increases the product viscosity. An easytodisperse crosslinked polyacrylic acid copolymer processed in a toxicologically preferred cosolvent system, it delivers excellent thickening efficiency and suspending capability, long viscous flow and sparkling clarity in gel systems.
Carbopol ultrez 21 polymer by lubrizol acts as a thickener, rheology modifier and suspending agent. Carbopol 940 255 43800 520 44400 2 carbopol 971p 114 2100 992 6200 99 carbopol 974p 55. Formulation responses like flux, lag time, diffusion coefficient, permeability coefficient and input rate were treated by design expert software version 8. Rutin wetted beads in developed pharmaceutical gel formulation showed higher. Get supplier listing of carbopol etd 2020, crosslinked polyacrylic acid copolymer and equal product. Optimizing surfactant systems thickened with carbopol etd 2020. Moreover, phosphate buffer and triethanolamine solutions ph 7.
An easytodisperse crosslinked polyacrylic acid copolymer, it delivers excellent thickening efficiency and suspending capability, long viscous flow and. An easytodisperse crosslinked polyacrylic acid copolymer, it delivers excellent thickening efficiency and suspending capability, long viscous flow and sparkling clarity in gel systems. This request for quotation will be sent to the supplier directly. Formulation and in vitro evaluation of carbopol 934based modified clotrimazole gel for topical application muhammad ubaid1, sadaf ilyas1, sadullah mir2, abida k. Carbopol 980 and 954 carbopol ez products are crosslinked polymers based on acrylic acid that are modified to make them very easy to add to water without lumping. Structural analysis of ciprofloxacincarbopol polymeric. Carbopol ultrez 20 polymer is designed to have higher electrolyte tolerance and handle a higher level of surfactant actives. It has been designed by balancing crosslinker levels with optimized hydrophobic content to provide efficient viscosity, thermal stability, as well. At incredibly low levels, carbopol ez 2 can turn water into a smooth, nonstringy syrup or a crystalclear non. Various batches of glp beads were prepared by an emulsionsolvent evaporation technique using the releaseretarding polymer carbopol and subjected to a systematic. Results of the fitting with the herschelbulkley model. The quantity of neutralizer that is added depends on the degree of thickening.
Oneway anova with p carbopol options are available to you, there are 1,772 suppliers who sells carbopol on, mainly located in asia. Composition and information on ingredients version. Application of a factorial design to the study of the. Rheological characterization of carbopol 940 in steady shear. Formulation and in vitro evaluation of carbopol 934based. Mix ingredients in part b and add to part a until completely mixed. Rheological characterization of carbopol 940 in steady. Possesses a medium yield value and resistance to ions. Carbopol etd 2020 polymer cosmetics ingredients specialchem. The present study analyzed the thickening properties of carbopol 974 and. Carbopol etd 2020 was chosen due to its interesting toxicologic reynier et al. Carbomer problems formulating shampoo cosmetic science. An easytodisperse crosslinked polyacrylic acid copolymer processed in a toxicologically preferred cosolvent system, it delivers excellent thickening efficiency and suspending capability, long.
The aim of the present study was to develop sustained release formulation of isoniazide to maintain constant therapeutic levels of the drug for over 12 hrs. Carbopol polymer is the easiest dispersing carbomer polymer available today for use in clear gels and emulsion systems, such as creams and lotions. Various batches of glp beads were prepared by an emulsionsolvent evaporation technique using the releaseretarding polymer carbopol and subjected to a systematic evaluation. Ultrez 30 polymer, carbopol 934, and carbopol ez2 both as a raw material for formulators, as well as in customized enduse gel applications. Rheological characterization of carbopol dispersions in. The best fit model was selected based adjusted multiple correlation coefficients adjusted r2.
Carbopol gel systems have been studied using steady, oscillatory rheology, and cryoscanning electron microscopy cryosem analysis in order to elucidate the nature of the different microstructures of the gel in relation to polymer concentration as well as triethanolamine tea content. Carbopol and sodium carboxymethylcellulose based methylsulfonylmethane gels for treatment of osteoarthritis. Carbopol ultrez 30 polymer coptis ingredients database. Carbopol microgels show much more pseudoplastic behavior lower power law index compared to carbopol gels dissolved only in water. Carbopol ultrez 20 and ultrez 21 are much better suited to this type of product than carbopol 940 uk based formulation chemist. Carbopol 974p is a negatively charged, high molecular weight, crosslinked, polyacrylic acid. Carbopol 934, 940 and ultrez 10 as viscosity modifiers of. The influence of the solvent type on the rheological properties of carbopol nf 980 dispersions in water and in waterglycerol solutions is investigated. It is an easytodisperse, crosslinked polyacrylic acid copolymer polymerized in a toxicologicallypreferred cosolvent system. Conditions for safe storage, including any incompatibilities storage conditions.
Us20140242023a1 topical compositions and methods of using. Polymers and compositions lubrizol advanced materials. The gel samples exhibit modest thixotropy at higher deformation rates. The top countries of suppliers are india, china, and taiwan, china, from which the percentage of carbopol supply is 1%, 98%, and 1% respectively.
Rheological properties and microstructures of carbopol gel. Carbopol etd 2020, nf polymer was found to not be suitable for use with. Ftir study was performed to evaluate compactability between drug and polymer utilized in study. Pdf carbopol and sodium carboxymethylcellulose based. Hydrophilic matrix tablets based on carbopol for improving. Our customized gels are used in medical devises, recreational innovations, and anywhere else the temperature control and protective benefits of gel based padding is. Pdf carbopolguar gum gel as a vehicle for topical gel. Formulation and evaluation of in situ gels containing. Rheological characterization of topical carbomer gels. Carbopol ultrez 30 polymer is a crosslinked homopolymer of acrylic acid that has been designed with a unique structure to allow the thickening and stabilization of cosmetic products. Carbopol etd 2691 offers resistance to the formation of lumps when dispersing in water. Products assnwhole foodsnational organic program guidelines focused skincare. Carbopol 934 c934 is a mucoadhesive, biodegradable and environmentally responsive carbopol polymer and is considered as smart gels.
Exhibits a long flow rheology when properly dispersed and neutralized. Carbopol etd 2020 nf is designed to provide increased electrolyte tolerance in drug formulations. It must be inducted at a very low rate in order to ensure complete dispersion on the first pass. It has been showed by srividya et al, that carbopol could show better sol to gel conversion at ph 7. Stabiliser et suspendre sans viscoser et en toute transparence, le polymere carbopol etd 2050 est lallie ideal des gels hydroalcooliques. Carbopol etd 2020 polymer by lubrizol is a thickener, rheology modifier and suspending agent. The effect of changing the concentration of carbopol 0. Application of a factorial design to the study of the flow behavior. Apr 21, 2009 only carbopol etd 2020 could yield clear gel without disturbing the microstructure of the cmz microemulsion. Transient and steadystate experiments were performed. This may be attributed to the lower ph of simulated salivary fluid ph 6. While we dont recommend homogenization, in cases where the formulation may require it, such as an emulsion, we recommend doing so before neutralization at the lowest. Carbopol etd 2020 polymer recommended use of the chemical and restrictions on use cosmetic applications. Carbopol etd 2020 polymer by lubrizol personal care.
Learn more about hansen solubility parameters hsp and their use in predictive formulation. Characterization of carbopol hydrogel rheology for. Formulation of isoniazide sustained release formulation by. Substantial yield strength is required to break the microgel network of the topical gels. Carbopol etd 2691 by lubrizol is a crosslinked acrylic acid polymer. Carbopol sc200 polymer coptis ingredients database. For both solvent types, a clearly thixotropic behavior occurs. The material formulation, preparation procedure, common experimental challenges and artifact sources are all addressed. Acrylatesc1030 alkyl acrylate crosspolymer quick start guide introduction benefits carbopol ultrez 20 polymer is a selfwetting, rapid selfwetting polymer, that rheology modifier designed to impart moderateto requires no dispersion agitation high viscosity as well as stabilizing and suspending. Carbopol etd 2020 polymer is an easytodisperse crosslinked polyacrylic acid. In this study, aqueous carbopol 940 solutions with different concentrations were used to provide a fundamental information in application of pharmaceutical and cosmetic areas. Carbopol ultrez 10 polymer is a crosslinked polyacrylic acid polymer that provides efficient rheology modification with enhanced selfwetting for ease of use. The ir spectrum of physical mixture of drug and polymers is characterized by principal absorption peaks at 2935.
This is a common characteristic of other carbopol polymers such as carbopol etd 2050 or 981 polymers, which are generally more sensitive than carbopol ultrez 10 or 980 polymers. Based on these results, in the present study we introduced 15% hydrophilic matrix forming polymer in the formulation. Mar 27, 2020 find products that are predicted to be compatible with carbopol etd 2050 polymer. Carbopolguar gum gel as a vehicle for topical gel formulation of pectin beads loaded with rutin.
Productvision software is the global choice to solve the problems of managing. Furthermore, carbopols are known to have mucoadhesive properties and have been used in the formulation vaginal delivery systems 7,8,16. Sanchez department of pharmacy and pharmaceutical technology, school of pharmacy, uni ersity of granada, campus of cartuja, e18071 granada, spain. C 71 to c 971, polymers with a low of crosslinking degree, and c 974, a carbopol with a high crosslinking degree. Store in tightly sealed containers in a dry and cool room. Kanwal1, ahmad 1nawaz1, amna shah1 and ghulam murtaza.